Daniel Côté, professeur agrégé
Pavillon d'Optique photonique - Local 2141
T. 418 656-2131 poste 412510
Champs d'intérêts
  • Neurophotonique
  • Biophotonique
  • Maladie du cerveau (sclérose en plaque, douleur chronique, Parkinson)




  • PHY-2004, GPH-2005 : Optique et optique instrumentale
  • GPH-2004 : Travaux pratique en optique photonique I
  • PHY-7093: Travaux pratique en biophotonique
  • BPH-7005 : Imagerie biomedicale
  • BPH-7006 : Optique Linéaire et Nonlinéaire des tissus



[1]         V. Breton-Provencher, D. Côté, and A. Saghatelyan, “Activity of the Principal Cells of the Olfactory Bulb Promotes a Structural Dynamic on the Distal Dendrites of Immature Adult-Born Granule Cells via Activation of NMDA Receptors,” J Neurosci, vol. 34, no. 5, pp. 1748–1759, Jan. 2014.

[2]         A. Gasecka, A. Daradich, H. Dehez, M. Piché, and D. Côté, “Resolution and contrast enhancement in coherent anti-Stokes Raman-scattering microscopy.,” Opt Lett, vol. 38, no. 21, pp. 4510–4513, Nov. 2013.

[3]         S. Bégin, E. Bélanger, S. Laffray, B. Aubé, É. Chamma, J. Bélisle, S. Lacroix, Y. De Koninck, and D. Côté, “Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach,” Biomed Opt Express, vol. 4, no. 10, pp. 2003–2014, 2013.

[4]         E. Bélanger, J. Crépeau, S. Laffray, R. Vallée, Y. De Koninck, and D. Côté, “Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy,” J Biomed Opt, vol. 17, no. 2, pp. 021107–021107–7, 2012.

[5]         E. Bélanger, F. P. Henry, R. Vallée, M. A. Randolph, I. E. Kochevar, J. M. Winograd, C. P. Lin, and D. Côté, “In vivo evaluation of demyelination and remyelination in a nerve crush injury model.,” Biomed Opt Express, vol. 2, no. 9, pp. 2698–2708, Sep. 2011.

[6]         S. M. Choi, W. H. Kim, D. Côté, C.-W. Park, and H. Lee, “Blood cell assisted in vivo Particle Image Velocimetry using the confocal laser scanning microscope.,” Opt. Expr., vol. 19, no. 5, pp. 4357–4368, Feb. 2011.

[7]         J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice.,” J Biomed Opt, vol. 16, no. 2, p. 021109, Feb. 2011.

[8]         O. D. Therrien, B. Aubé, S. Pagès, P. D. Koninck, and D. Côté, “Wide-field multiphoton imaging of cellular dynamics in thick tissue by temporal focusing and patterned illumination.,” Biomed Opt Express, vol. 2, no. 3, pp. 696–704, 2011.

[9]         S. Bégin, B. Burgoyne, V. Mercier, A. Villeneuve, R. Vallée, and D. Côté, “Coherent anti-Stokes Raman scattering hyperspectral tissue imaging with a wavelength-swept system.,” Biomed Opt Express, vol. 2, no. 5, pp. 1296–1306, 2011.

[10]       S. Pagès, D. Côté, and P. De Koninck, “Optophysiological approach to resolve neuronal action potentials with high spatial and temporal resolution in cultured neurons.,” Front Cell Neurosci, vol. 5, p. 20, 2011.

[11]       J. Fujisaki, J. Wu, A. L. Carlson, L. Silberstein, P. Putheti, R. Larocca, W. Gao, T. I. Saito, C. lo Celso, H. Tsuyuzaki, T. Sato, D. Côté, M. Sykes, T. B. Strom, D. T. Scadden, and C. P. Lin, “In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.,” Nature, vol. 474, no. 7350, pp. 216–219, 2011.

[12]       S. Laffray, S. Pagès, H. Dufour, P. De Koninck, Y. De Koninck, and D. Côté, “Adaptive Movement Compensation for In Vivo Imaging of Fast Cellular Dynamics within a Moving Tissue.,” PLoS ONE, vol. 6, no. 5, p. e19928, 2011.

[13]       Chunqiang Li, C. Pitsillides, J. M. Runnels, D. Côté, and C. P. Lin, “Multiphoton Microscopy of Live Tissues With Ultraviolet Autofluorescence,” Ieee J Sel Top Quant, vol. 16, no. 3, pp. 516–523, May 2010.

[14]       C. Li, R. K. Pastila, C. Pitsillides, J. M. Runnels, M. Puoris'haag, D. Côté, and C. P. Lin, “Imaging leukocyte trafficking in vivo with two-photon-excited endogenous tryptophan fluorescence,” Opt. Expr., vol. 18, no. 2, pp. 988–999, 2010.

[15]       S. Bégin, E. Bélanger, S. Laffray, R. Vallée, and D. Côté, “In vivo optical monitoring of tissue pathologies and diseases with vibrational contrast.,” J Biophotonics, vol. 2, no. 11, pp. 632–642, Nov. 2009.

[16]       F. P. Henry, D. Côté, M. A. Randolph, E. A. Z. Rust, R. W. Redmond, I. E. Kochevar, C. P. Lin, and J. M. Winograd, “Real-time in vivo assessment of the nerve microenvironment with coherent anti-Stokes Raman scattering microscopy.,” Plast. Reconstr. Surg., vol. 123, no. 2, pp. 123S–30S, Feb. 2009.

[17]       C. lo Celso, H. E. Fleming, J. W. Wu, C. X. Zhao, S. Miake-Lye, J. Fujisaki, D. Côté, D. W. Rowe, C. P. Lin, and D. T. Scadden, “Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.,” Nature, vol. 457, no. 7225, pp. 92–96, Jan. 2009.

[18]       E. Bélanger, S. Bégin, S. Laffray, Y. De Koninck, R. Vallée, and D. Côté, “Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: alleviating the excitation polarization dependence with circularly polarized laser beams,” Opt. Expr., vol. 17, no. 21, pp. 18419–18432, 2009.

[19]       M. F. G. Wood, D. Côté, and I. A. Vitkin, “Combined optical intensity and polarization methodology for analyte concentration determination in simulated optically clear and turbid biological media.,” J Biomed Opt, vol. 13, no. 4, p. 044037, Jun. 2008.

[20]       I. Veilleux, J. Spencer, D. Biss, D. Côté, and C. P. Lin, “In Vivo Cell Tracking With Video Rate Multimodality Laser Scanning Microscopy,” IEEE J. Quant. Elect., vol. 14, no. 1, pp. 10–18, Jan. 2008.

[21]       P. Kim, M. Puoris'haag, D. Côté, C. P. Lin, and S. H. Yun, “In vivo confocal and multiphoton microendoscopy.,” J Biomed Opt, vol. 13, no. 1, p. 010501, 2008.

[22]       E. Bélanger, M. Bernier, D. Faucher, D. Côté, and R. Vallée, “High-Power and Widely Tunable All-Fiber Raman Laser,” Lightwave Technology, Journal of, vol. 26, no. 9, pp. 1696–1701, 2008.

[23]       E. Bélanger, M. Bernier, J. P. Bérubé, B. Déry, S. Gagnon, D. Côté, and R. Vallée, “Two different mechanical tuning devices of fiber Bragg gratings,” Proc. SPIE Int. Soc. Opt. Eng., vol. 6796, no. 1, pp. 67962Q–11, Jun. 2007.

[24]       E. Bélanger, M. Bernier, D. Côté, and R. Vallée, “All-fiber Raman laser tuned over 60nm,” Proc. SPIE Int. Soc. Opt. Eng., vol. 6796, no. 1, pp. 67960V–5, Jun. 2007.

[25]       Y. Alsayed, H. Ngo, J. Runnels, X. Leleu, U. K. Singha, C. M. Pitsillides, J. A. Spencer, T. Kimlinger, J. M. Ghobrial, X. Jia, G. Lu, M. Timm, A. Kumar, D. Côté, I. Veilleux, K. E. Hedin, G. D. Roodman, T. E. WitZig, A. L. Kung, T. Hideshima, K. C. Anderson, C. P. Lin, and I. M. Ghobrial, “Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.,” Blood, vol. 109, no. 7, pp. 2708–2717, Apr. 2007.

[26]       M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice.,” J Biomed Opt, vol. 12, no. 3, p. 034018, Apr. 2007.

[27]       D. P. Biss, D. Sumorok, S. A. Burns, R. H. Webb, Y. Zhou, T. G. Bifano, D. Côté, I. Veilleux, P. Zamiri, and C. P. Lin, “In vivo fluorescent imaging of the mouse retina using adaptive optics,” Opt Lett, vol. 32, no. 6, pp. 659–661, Jan. 2007.

[28]       C. Alt, I. Veilleux, H. Lee, C. M. Pitsillides, D. Côté, and C. P. Lin, “Retinal flow cytometer,” Opt Lett, vol. 32, no. 23, pp. 3450–3452, 2007.

[29]       R. Chakraverty, D. Côté, J. Buchli, P. Cotter, R. Hsu, G. Zhao, T. Sachs, C. M. Pitsillides, R. Bronson, T. Means, C. P. Lin, and M. Sykes, “An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues.,” J Exp Med, vol. 203, no. 8, pp. 2021–2031, Aug. 2006.

[30]       C. L. Evans, E. O. Potma, M. Puoris'haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 46, pp. 16807–16812, Nov. 2005.

[31]       D. A. Sipkins, X. Wei, J. W. Wu, J. M. Runnels, D. Côté, T. K. Means, A. D. Luster, D. T. Scadden, and C. P. Lin, “In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.,” Nature, vol. 435, no. 7044, pp. 969–973, Jun. 2005.

[32]       D. Côté and A. Vitkin, “Robust concentration determination of optically active molecules in turbid media with validated three-dimensional polarization sensitive Monte Carlo calculations,” Opt. Expr., vol. 13, no. 1, pp. 148–163, 2005.

[33]       C. A. Rendon, D. Côté, L. Vesselov, and L. Lilge, “Characterization of the Modeled Fluence Distribution of Real Cylindrical Diffusers in the Intraluminal and Interstitial Settings,” presented at the Therapeutic Laser Applications and Laser-Tissue Interactions II, 2005, p. TuA2.

[34]       D. Côté and I. A. Vitkin, “Balanced detection for low-noise precision polarimetric measurements of optically active, multiply scattering tissue phantoms,” J Biomed Opt, vol. 9, no. 1, pp. 213–220, Jan. 2004.

[35]       D. Côté, J. Sipe, and H. van Driel, “Simple Method for Calculating the Propagation of THz Radiation In Experimental Geometries,” Journ. Opt. Soc. Am. B, 2003.

[36]       D. Côté, N. Laman, and H. van Driel, “Rectification and shift currents in GaAs,” Appl Phys Lett, vol. 80, no. 6, p. 905, 2002.

[37]       D. Côté, J. Fraser, M. DeCamp, P. Bucksbaum, and H. van Driel, “THz radiation from coherently-controlled photocurrents in GaAs,” Appl Phys Lett, vol. 75, no. 25, p. 3959, 1999.

[38]     D. Côté and H. van Driel, “Period doubling of a femtosecond Ti:sapphire laser by total mode locking,” Opt Lett, vol. 23, p. 715, 1998.



  • COPL : Centre d’optique Photonique et Laser (Directeur axe Biophotonique)
  • CRCN : Centre de Recherche en Neurosciences


Formation et expériences professionnelles


  • Baccalauréat ès sciences (Université Laval, 1995)
  • M.Sc.- Physics (University of Toronto, 1996)
  • Ph.D.- Physics (University of Toronto, 2003)


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